Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11183365 | 0.84 | POLB (0.38) | FFAR2 | |
| SCHEMBL11219793 | 0.81 | ACE (0.43) | HTTACELMNAFFAR2 | |
| SCHEMBL11259834 | 0.81 | PDE5A (0.33) | HTTLMNA | |
| SCHEMBL11104668 | 0.74 | ACE (0.48) | ACELMNAFFAR2 | |
| SCHEMBL11104265 | 0.74 | ACE (0.46) | HTTACELMNAFFAR2 | |
| SCHEMBL11194036 | 0.69 | ACE (0.59) | HTTACELMNAFFAR2 | |
| SCHEMBL11104269 | 0.66 | LMNA (0.46) | HTTACELMNAFFAR2 | |
| SCHEMBL11219804 | 0.64 | ACE (0.36) | HTTACELMNAFFAR2 | |
| SCHEMBL11196508 | 0.64 | ACE (0.55) | HTTACELMNAFFAR2 | |
| SCHEMBL11185141 | 0.63 | GAA (0.66) | HTTFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |