SCHEMBL11221049

SCHEMBL11221049

CS(=O)(=O)c1ccc(CNc2ccc(S(=O)(=O)O)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 0.54
CA2 P00918 6/20 0.54
CA9 Q16790 4/20 0.54
CA12 O43570 3/20 0.54
GHSR Q92847 13/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22869532 0.87 MEN1 (0.62) CA1CA2CA9CA12
SCHEMBL11226800 0.87 CA1 (0.71) CA1CA2CA9CA12
SCHEMBL11238590 0.83 HDAC1 (0.56) CA1CA2CA9CA12
SCHEMBL1145886 0.83 GHSR (0.60) CA1CA2CA9CA12GHSR
SCHEMBL11226491 0.83 AGER (0.62) CA1CA2CA9CA12
SCHEMBL28370860 0.83 ALDH1A1 (0.60) CA1CA2CA9CA12
SCHEMBL29151673 0.83 CA1 (0.60) CA1CA2CA9CA12
SCHEMBL9189617 0.83 CA1 (0.70) CA1CA2CA9CA12
SCHEMBL209732 0.83 KMT2A (0.58) CA1CA2CA9CA12GHSR
SCHEMBL11233483 0.83 CA1 (0.57) CA1CA2CA9CA12GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4328244-A ANTIVIRAL AGENT THE DOW CHEMICAL COMPANY (US) 1982-05-04 US claimed
US-4328244-A ANTIVIRAL AGENT THE DOW CHEMICAL COMPANY (US) 1982-05-04 US disclosed