Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406677 | 0.77 | NOS2 (0.31) | — | |
| Proline SCHEMBL11221271 | 0.77 | SMYD3 (0.38) | — | |
| Proline SCHEMBL6690175 | 0.77 | SMYD3 (0.38) | — | |
| Proline SCHEMBL28396348 | 0.77 | SMYD3 (0.38) | — | |
| Proline SCHEMBL5860492 | 0.77 | NOS2 (0.37) | — | |
| Proline SCHEMBL1675452 | 0.77 | NOS2 (0.37) | — | |
| Proline SCHEMBL3100537 | 0.77 | NOS2 (0.37) | — | |
| Proline SCHEMBL3089157 | 0.77 | NOS2 (0.37) | — | |
| Proline SCHEMBL1702869 | 0.77 | NOS2 (0.37) | — | |
| Proline SCHEMBL8720004 | 0.77 | NOS2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57165356-A | — | — | None | — | — | JP | disclosed |
| JP-S57165356-A | ACTIVE PEPTIDE | TOHO SHINYAKU KK | 1982-10-12 | — | — | JP | disclosed |