Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13396971 | 0.82 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL25946352 | 0.80 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL10925572 | 0.80 | PAK4 (0.31) | PAK4 | |
| SCHEMBL11221495 | 0.78 | GABRA1 (0.30) | — | |
| SCHEMBL25928367 | 0.76 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL16248170 | 0.74 | DHFR (0.31) | — | |
| SCHEMBL25928446 | 0.72 | — | — | |
| SCHEMBL25928457 | 0.72 | JAK2 (0.36) | PAK4 | |
| SCHEMBL17423958 | 0.72 | ALDH1A1 (0.41) | — | |
| SCHEMBL31281424 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4343802-A | ADRENERGIC BLOCKING, ANTIARRYHYTHMIA, AND CARDIOTONIC AGENTS | MERCK, SHARP & DOHME (I.A.) CORP. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4193995-A | B-ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1980-03-18 | — | — | US | disclosed |
| US-4042586-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1977-08-16 | — | — | US | disclosed |
| US-3946009-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1976-03-23 | — | — | US | disclosed |