Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 11/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11215534 | 0.86 | PNP (0.53) | PNPADORA2AADORA2BPDE2APDE1A | |
| SCHEMBL11222783 | 0.82 | PNP (0.36) | PNPADORA2AADORA2BPDE2APDE1A | |
| SCHEMBL6035390 | 0.74 | PNP (0.63) | PNPADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL563300 | 0.74 | ADORA2B (0.63) | PNPADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL5667530 | 0.73 | ADORA2A (0.61) | PNPADORA2AADORA2BPDE2APDE1A | |
| SCHEMBL29015263 | 0.73 | ADORA2A (0.61) | PNPADORA2AADORA2BPDE2APDE1A | |
| SCHEMBL10591050 | 0.70 | PNP (0.50) | PNPADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL48434 | 0.69 | ATAD2 (0.54) | PNPADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL16494563 | 0.69 | PNP (0.52) | PNPADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL28633086 | 0.69 | PNP (0.52) | PNPADORA2AADORA2BPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1982002202-A1 | NOVEL DERIVATIVES OF GUANINE | ASTRA LAEKEMEDEL AB (SE) | 1982-07-08 | — | — | WO | disclosed |