Xanthene

Xanthene

SCHEMBL11222980

[Zn].c1ccc2c(c1)Cc1ccccc1O2

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.94
MAOB P27338 2/20 0.94
GAA P10253 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
NPC1 O15118 1/20 0.44
LMNA P02545 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAPKAPK2 P49137 1/20 0.43
ACSL1 P33121 1/20 0.41
ALOX5 P09917 1/20 0.40
ABCG2 Q9UNQ0 1/20 0.39
ITGB2 P05107 1/20 0.39
ICAM1 P05362 1/20 0.39
ITGAL P20701 1/20 0.39
OXTR P30559 1/20 0.38
CYP1A2 P05177 1/20 0.38
HTR2A P28223 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Xanthene SCHEMBL28879157 0.97 MAOA (0.90) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL30586075 0.97 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL27493963 0.97 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL9339684 0.97 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL4267 0.97 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL29378346 0.97 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL23355281 0.94 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL1673119 0.94 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL11214757 0.94 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL6192065 0.94 MAOA (0.94) MAOAMAOBGAANPSR1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1982001554-A1 POLYCARBONATES STABILIZED BY HALOHYDROCARBON,HALOCARBON OR SILANE GROUPS MCALISTER ROY E 1982-05-13 WO disclosed
EP-0027144-A4 POLYCARBONATES STABILIZED BY HALOHYDROCARBON, HALOCARBON OR SILANE GROUPS. MCALISTER ROY E 1981-05-19 EP disclosed
EP-0027144-A1 POLYCARBONATES STABILIZED BY HALOHYDROCARBON, HALOCARBON OR SILANE GROUPS McALISTER, Roy Edward (US) 1981-04-22 EP disclosed
WO-1980002290-A1 POLYCARBONATES STABILIZED BY HALOHYDROCARBON,HALOCARBON OR SILANE GROUPS MCALISTER R 1980-10-30 WO disclosed