Xanthene

Xanthene

SCHEMBL9339684

c1ccc2c(c1)Cc1ccccc1O2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 1.00
MAOB P27338 2/20 1.00
GAA P10253 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
NPC1 O15118 1/20 0.45
LMNA P02545 1/20 0.45
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
MAPKAPK2 P49137 1/20 0.44
ALOX5 P09917 1/20 0.42
ACSL1 P33121 1/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
ITGB2 P05107 1/20 0.41
ICAM1 P05362 1/20 0.41
ITGAL P20701 1/20 0.41
OXTR P30559 1/20 0.39
CYP1A2 P05177 1/20 0.39
HTR2A P28223 1/20 0.39
AHR P35869 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Xanthene SCHEMBL29378346 1.00 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL30586075 1.00 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL4267 1.00 MAOA (1.00) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL11600668 0.97 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL1673119 0.97 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL23355281 0.97 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL6192065 0.97 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL11222980 0.97 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL11214757 0.97 MAOA (0.94) MAOAMAOBGAANPSR1NPC1
Xanthene SCHEMBL11600218 0.97 MAOA (0.94) MAOAMAOBGAANPSR1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0392805-B1 Hydrazones and electrophotographic photoreceptors comprising them MITSUI TOATSU CHEMICALS (JP) 1994-06-15 EP claimed
US-5235104-A Charge transport materials MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1993-08-10 US claimed
US-5132190-A Froma triphenylamine aldehyde MITSUI TOATSU CHEMICALS INCORPORATED (JP) 1992-07-21 US claimed
EP-0392805-A1 Hydrazones and electrophotographic photoreceptors comprising them MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-10-17 EP claimed
CN-101952336-A Amine catalysts for polyurethane foams HONEYWELL INT INC 2011-01-19 CN disclosed
EP-0392805-B1 Hydrazones and electrophotographic photoreceptors comprising them MITSUI TOATSU CHEMICALS (JP) 1994-06-15 EP disclosed
US-5235104-A Charge transport materials MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1993-08-10 US disclosed
US-5132190-A Froma triphenylamine aldehyde MITSUI TOATSU CHEMICALS INCORPORATED (JP) 1992-07-21 US disclosed
EP-0392805-A1 Hydrazones and electrophotographic photoreceptors comprising them MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-10-17 EP disclosed
US-4101464-A Process for preparing foamed solids using two or more azo compounds PENNWALT CORPORATION (US) 1978-07-18 US disclosed
US-4029615-A AZO COMPOUNDS PENNWALT CORPORATION (US) 1977-06-14 US disclosed
US-3993609-A ACID SENSITIVE AZO PROMOTERS PENNWALT CORPORATION (US) 1976-11-23 US disclosed