Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Xanthene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.40 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.94 |
| ▸ | MAOB | P27338 | 2/20 | 0.94 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xanthene SCHEMBL8797707 | 1.00 | MAOA (0.94) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL11602030 | 0.97 | MAOA (0.90) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL27884847 | 0.97 | MAOA (0.90) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL28879157 | 0.97 | MAOA (0.90) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL27493963 | 0.97 | MAOA (1.00) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL4267 | 0.97 | MAOA (1.00) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL30586075 | 0.97 | MAOA (1.00) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL9339684 | 0.97 | MAOA (1.00) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL29378346 | 0.97 | MAOA (1.00) | MAOAMAOBGAANPSR1MAPKAPK2 | |
| Xanthene SCHEMBL23355281 | 0.94 | MAOA (0.94) | MAOAMAOBGAANPSR1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085267-B | Method for detecting ethyl carbamate | 华南农业大学 | 2023-04-25 | — | — | CN | claimed |
| CN-114230632-B | Acrylamide derivative mimic epitope peptide and application thereof | 华南农业大学 | 2023-01-24 | — | — | CN | claimed |
| CN-114230632-A | Acrylamide derivative mimic epitope peptide and application thereof | 华南农业大学 | 2022-03-25 | — | — | CN | claimed |
| CN-114085267-A | Method for detecting ethyl carbamate | 华南农业大学 | 2022-02-25 | — | — | CN | claimed |
| CN-114107113-B | Method for reducing ethyl carbamate in fermented food by using synthetic starter | 江南大学 | 2023-07-18 | — | — | CN | disclosed |
| WO-2023093960-A1 | MODIFIED PEPTIDE-OLIGONUCLEOTIDE CONJUGATE | SYDDANSK UNIVERSITET (DK) | 2023-06-01 | — | — | WO | disclosed |
| CN-114085267-B | Method for detecting ethyl carbamate | 华南农业大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-113913314-B | Strain for reducing accumulation of urea and ethyl carbamate in yellow wine and application thereof | 江南大学 | 2023-02-24 | — | — | CN | disclosed |
| CN-114230632-B | Acrylamide derivative mimic epitope peptide and application thereof | 华南农业大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-114230632-A | Acrylamide derivative mimic epitope peptide and application thereof | 华南农业大学 | 2022-03-25 | — | — | CN | disclosed |
| CN-114107113-A | Method for reducing ethyl carbamate in fermented food by using synthetic leavening agent | 江南大学 | 2022-03-01 | — | — | CN | disclosed |
| CN-114085267-A | Method for detecting ethyl carbamate | 华南农业大学 | 2022-02-25 | — | — | CN | disclosed |
| WO-1993004580-A1 | N-(4-PYRIDYL OR 4-QUINOLINYL) ARYLACETAMIDE PESTICIDES | DOWELANCO (US) | 1993-03-18 | — | — | WO | disclosed |
| WO-1993005050-A1 | 4-(ARALKOXY OR ARALKYLAMINO)PYRIDINE PESTICIDES_________________ | DOWELANCO (US) | 1993-03-18 | — | — | WO | disclosed |
| WO-1993004579-A1 | NEMATICIDAL USE OF 4-ARALKYLPYRIDINES | DOWELANCO (US) | 1993-03-18 | — | — | WO | disclosed |
| US-5137879-A | Fungicide, miticide and insecticide | DOWELANCO (US) | 1992-08-11 | — | — | US | disclosed |
| US-5034393-A | Fungicides for plants | DOWELANCO (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0414386-A1 | Condensed pyrimidine derivates | DowElanco (US) | 1991-02-27 | — | — | EP | disclosed |
| EP-0410762-A1 | Naphthyridine derivatives | DowElanco (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0326329-A2 | Quinazoline derivatives | DowElanco (US) | 1989-08-02 | — | — | EP | disclosed |