Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.35 |
| ▸ | PRKCA | P17252 | 3/20 | 0.35 |
| ▸ | PRKCH | P24723 | 2/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235434 | 0.83 | PRKCD (0.51) | MAPTPDE7APRKCDPRKCAPRKCH | |
| SCHEMBL11238719 | 0.80 | GAA (0.47) | MAPTPDE7APRKCACYP1A2ALDH1A1 | |
| SCHEMBL11231870 | 0.79 | HDAC2 (0.46) | PRKCDPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL11233747 | 0.78 | GLA (0.50) | GLAMAPTCYP1A2ALDH1A1SYK | |
| SCHEMBL11233319 | 0.76 | L3MBTL1 (0.52) | MAPTPDE7APRKCDPRKCAPRKCH | |
| SCHEMBL5832744 | 0.76 | TXNRD1 (0.46) | GLAMAPTHTT | |
| SCHEMBL11235404 | 0.75 | POLB (0.45) | MAPTPDE7APRKCAALDH1A1GAA | |
| SCHEMBL11231846 | 0.75 | POLB (0.52) | MAPTPDE7APRKCDPRKCHPRKCE | |
| SCHEMBL10352588 | 0.75 | MAPT (0.54) | GLAMAPTCYP1A2ALDH1A1HTT | |
| SCHEMBL11241875 | 0.75 | POLB (0.47) | MAPTPDE7APRKCACYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |