Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270728 | 0.83 | LMNA (0.47) | PLAUMEN1KMT2AKDM4ENOS3 | |
| SCHEMBL3231973 | 0.83 | UHRF1 (0.43) | PLAUMEN1KMT2AKDM4ENOS3 | |
| SCHEMBL14344868 | 0.81 | PLAU (0.44) | PLAUMEN1KMT2AKDM4ENOS3 | |
| SCHEMBL9572453 | 0.79 | MEN1 (0.53) | PLAUMEN1KMT2AKDM4ENOS3 | |
| SCHEMBL18214846 | 0.79 | PLAU (0.42) | PLAUMEN1KMT2AKDM4ENOS3 | |
| SCHEMBL28741813 | 0.79 | MEN1 (0.41) | MEN1KMT2AKDM4ENOS3NOS1 | |
| SCHEMBL28909873 | 0.78 | PLAU (0.39) | PLAUMEN1KMT2AKDM4ENOS3 | |
| SCHEMBL29110383 | 0.78 | MEN1 (0.38) | MEN1KMT2AKDM4ELOXLOXL2 | |
| SCHEMBL17593320 | 0.78 | KMT2A (0.38) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5784920 | 0.78 | ALDH1A1 (0.39) | MEN1KMT2AKDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440817-A | RNAi agents for inhibiting expression of advanced glycation end product receptors, compositions and methods of use thereof | 箭头药业股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-116444506-A | Therapeutic compounds and compositions | 艾克赛特赫拉制药有限责任公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-108892661-B | Therapeutic compounds and compositions | 艾克赛特赫拉制药有限责任公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-114846142-A | RNAi agents for inhibiting expression of beta-ENaC, compositions thereof, and methods of use | 箭头药业股份有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-111620867-A | Mesoionic insecticides | 东莞市东阳光农药研发有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-111526880-A | Integrin ligands and uses thereof | 箭头药业股份有限公司 | 2020-08-11 | — | — | CN | disclosed |
| EP-0012112-B1 | PRESSURE-SENSITIVE OR HEAT-SENSITIVE RECORDING MATERIAL | CIBA-GEIGY AG (CH) | 1983-10-05 | — | — | EP | disclosed |
| US-4291901-A | Pressure-sensitive or heat-sensitive recording material | CIBA-GEIGY CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |
| EP-0012112-A1 | Pressure-sensitive or heat-sensitive recording material | CIBA-GEIGY AG (CH) | 1980-06-11 | — | — | EP | disclosed |