Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083112 | 0.82 | PARP1 (0.47) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8920225 | 0.79 | SYK (0.43) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8920245 | 0.79 | SYK (0.43) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5196284 | 0.78 | PARP1 (0.53) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL497429 | 0.78 | PARP1 (0.53) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1937751 | 0.78 | PARP1 (0.53) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL353231 | 0.76 | KDM4E (0.55) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30666151 | 0.76 | PARP1 (0.51) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31439135 | 0.76 | PARP1 (0.51) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30011332 | 0.76 | KDM4E (0.55) | PARP1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931656-B1 | NOVEL DRUGS FOR DEMENTIA | TERNANSKY ROBERT (US) | 2011-02-09 | — | — | EP | disclosed |
| US-20080227806-A1 | Novel Drugs for Dementia | AMERICAN LIFE SCIENCE PHARMACEUTICALS (US) | 2008-09-18 | — | — | US | disclosed |
| US-20080161395-A1 | Derivatives of Aminobutanoic Acid Inhibiting Cpt | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-07-03 | — | — | US | disclosed |
| EP-1931656-A1 | NOVEL DRUGS FOR DEMENTIA | Ternansky, Robert (US) | 2008-06-18 | — | — | EP | disclosed |
| EP-1853556-A1 | DERIVATIVES OF AMINOBUTANOIC ACID INHIBITING CPT | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2007-11-14 | — | — | EP | disclosed |
| WO-2007038772-A1 | NOVEL DRUGS FOR DEMENTIA | AMERICAN LIFE SCIENCE PHARMACEUTICALS (US) | 2007-04-05 | — | — | WO | disclosed |
| WO-2006092204-A1 | DERIVATIVES OF AMINOBUTANOIC ACID INHIBITING CPT | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227806-A1 | Novel Drugs for Dementia | CTSS, PRSS1, CBS | PARP1 4208/4885KDM4E 3000/4885ALDH1A1 2533/4885 |
| US-20080161395-A1 | Derivatives of Aminobutanoic Acid Inhibiting Cpt | CPT1B, CPT1A, CPT2 | PARP1 2638/4885KDM4E 1498/4885ALDH1A1 677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.