Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11224968 | 1.00 | PDE3B (0.40) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11222392 | 0.87 | PDE3B (0.54) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11222395 | 0.87 | PDE3B (0.54) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11229983 | 0.83 | PDE3B (0.38) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11229981 | 0.83 | PDE3B (0.38) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11231386 | 0.82 | PDE3B (0.41) | PDE3BPDE3AABL1 | |
| SCHEMBL11231407 | 0.82 | PDE3B (0.41) | PDE3BPDE3AABL1 | |
| SCHEMBL11224303 | 0.80 | PDE3B (0.57) | PDE3BPDE3ACCNCCDK8CDK5 | |
| SCHEMBL11224300 | 0.80 | PDE3B (0.57) | PDE3BPDE3ACCNCCDK8CDK5 | |
| SCHEMBL11240170 | 0.76 | GPR142 (0.36) | PDE3BPDE3AABL1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |