Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229983 | 0.80 | PDE3B (0.38) | GPR142PDE3BPDE3APSEN1PSEN2 | |
| SCHEMBL11229981 | 0.80 | PDE3B (0.38) | GPR142PDE3BPDE3APSEN1PSEN2 | |
| SCHEMBL11224972 | 0.76 | PDE3B (0.40) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11224968 | 0.76 | PDE3B (0.40) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11243508 | 0.72 | PDE3B (0.43) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11244158 | 0.71 | CCNC (0.49) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11234122 | 0.71 | PDE3B (0.56) | GPR142PDE3BPDE3ACCNCCDK8 | |
| SCHEMBL11238599 | 0.71 | PDE3B (0.49) | PDE3BPDE3ACCNCCDK8MAPK1 | |
| SCHEMBL11236017 | 0.71 | MAPK1 (0.49) | PDE3BPDE3AABL1CCNCCDK8 | |
| SCHEMBL11236041 | 0.70 | PDE3B (0.41) | PDE3BPDE3AABL1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |