Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 6/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246747 | 0.86 | TDP1 (0.34) | KDM4EMAPK14MAPTPRMT5DYRK1A | |
| SCHEMBL11234950 | 0.83 | CDC7 (0.42) | MTORGSK3BCDC7PIM1HIPK2 | |
| SCHEMBL11238965 | 0.80 | CYP1A2 (0.42) | GSK3BCDC7PIM1HIPK2CLK4 | |
| SCHEMBL11243737 | 0.78 | PDE3B (0.43) | DAO | |
| SCHEMBL11234998 | 0.76 | ALDH1A1 (0.52) | GSK3BKDM4EMAPK1 | |
| SCHEMBL11243932 | 0.75 | MPO (0.40) | MTORGSK3BROCK2KDM4EMAPT | |
| SCHEMBL11230498 | 0.75 | ALDH1A1 (0.53) | MTORGSK3BKDM4EMAPK1DYRK1A | |
| SCHEMBL11238130 | 0.74 | ALDH1A1 (0.47) | GSK3BKDM4EMAPK1 | |
| SCHEMBL11230940 | 0.73 | CTDSP1 (0.46) | GSK3BKDM4EMAPK1MAPK14DYRK1A | |
| SCHEMBL11223721 | 0.72 | KDM4E (0.51) | GSK3BCDC7PIM1HIPK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |