Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 1/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | CASP1 | P29466 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229759 | 0.86 | GSK3B (0.46) | LATS1LATS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11231701 | 0.83 | PABPC1 (0.51) | ALDH1A1KDM4EHSD17B10L3MBTL1TP53 | |
| SCHEMBL11129400 | 0.81 | ADORA2A (0.41) | ALDH1A1KDM4EHSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL11235570 | 0.80 | GSK3B (0.51) | ALDH1A1KDM4EHSD17B10GSK3AGSK3B | |
| SCHEMBL11232136 | 0.77 | LATS1 (0.38) | LATS1LATS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11229298 | 0.77 | LATS1 (0.40) | LATS1LATS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11280195 | 0.77 | GSK3B (0.37) | ALDH1A1KDM4EHSD17B10L3MBTL1LMNA | |
| SCHEMBL11232705 | 0.73 | PDGFRB (0.38) | LATS1LATS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11231822 | 0.73 | GSK3A (0.37) | ALDH1A1KDM4EHSD17B10L3MBTL1TP53 | |
| SCHEMBL11233210 | 0.72 | MEN1 (0.43) | ALDH1A1KDM4EHSD17B10L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |