Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11231701 | 0.89 | PABPC1 (0.51) | MEN1KMT2AATMNTRK1CASP1 | |
| SCHEMBL11222288 | 0.87 | MEN1 (0.40) | MEN1KMT2AATMNTRK1CASP1 | |
| SCHEMBL11231889 | 0.85 | KDM4E (0.49) | MEN1KMT2ANTRK1CASP1ALDH1A1 | |
| SCHEMBL11238184 | 0.81 | MAPK10 (0.43) | MEN1KMT2ANTRK1CASP1MAPK10 | |
| SCHEMBL11229121 | 0.80 | MEN1 (0.41) | MEN1KMT2AATMCASP1ALDH1A1 | |
| SCHEMBL11226073 | 0.78 | ATM (0.45) | ATMCASP1ALDH1A1GSK3AGSK3B | |
| SCHEMBL11244896 | 0.77 | GSK3B (0.49) | NTRK1GSK3BSPRIKBKETBK1 | |
| SCHEMBL11234298 | 0.77 | ROCK2 (0.42) | MEN1KMT2ANTRK1CASP1ALDH1A1 | |
| SCHEMBL11227000 | 0.77 | ATM (0.42) | ATMCASP1ALDH1A1GSK3AGSK3B | |
| SCHEMBL11280195 | 0.74 | GSK3B (0.37) | MEN1KMT2AATMNTRK1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |