Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 2/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226073 | 0.82 | ATM (0.45) | GSK3BALDH1A1HSD17B10CASP1KDM4C | |
| SCHEMBL11226000 | 0.80 | GSK3B (0.49) | GSK3BNFATC1DYRK1AALDH1A1MEN1 | |
| SCHEMBL11238837 | 0.79 | DYRK1A (0.36) | ROCK2ROCK1GSK3BNFATC1DYRK1A | |
| SCHEMBL11225319 | 0.77 | LATS1 (0.40) | LATS1LATS2GSK3BALDH1A1MEN1 | |
| SCHEMBL11280195 | 0.77 | GSK3B (0.37) | GSK3BALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL11234009 | 0.73 | GSK3B (0.47) | ROCK2GSK3BNFATC1DYRK1AALDH1A1 | |
| SCHEMBL11229759 | 0.73 | GSK3B (0.46) | LATS1LATS2GSK3BALDH1A1MEN1 | |
| SCHEMBL11231822 | 0.73 | GSK3A (0.37) | GSK3BALDH1A1MEN1CYP3A4KMT2A | |
| SCHEMBL11222288 | 0.73 | MEN1 (0.40) | GSK3BALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL11227000 | 0.73 | ATM (0.42) | GSK3BALDH1A1CYP1A2CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |