Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244654 | 0.88 | SIGMAR1 (0.54) | ALDH1A1TSHRSIGMAR1MEN1TP53 | |
| SCHEMBL11230661 | 0.86 | SIGMAR1 (0.52) | HTR6TSHRSIGMAR1MEN1TP53 | |
| SCHEMBL11228025 | 0.85 | SIGMAR1 (0.59) | TSHRSIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL11249424 | 0.83 | KDM4E (0.53) | HTR1DHTR6ALDH1A1KDM4EHPGD | |
| SCHEMBL11243420 | 0.82 | HTR1A (0.69) | HTR1A | |
| Hydrochloric Acid SCHEMBL11224419 | 0.81 | HTR1A (0.68) | HTR1A | |
| SCHEMBL11787894 | 0.81 | CHRNA7 (0.52) | ALDH1A1SIGMAR1KMT2AMAPTHTR1A | |
| SCHEMBL11783437 | 0.81 | DRD2 (0.70) | SIGMAR1GAAHTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL11335313 | 0.80 | DRD2 (0.69) | ALDH1A1GAAHTR1ASLC6A2 | |
| SCHEMBL11338350 | 0.79 | CHRNA7 (0.50) | HSD17B10SIGMAR1KMT2AHTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |