Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.71 |
| ▸ | CA2 | P00918 | 3/20 | 0.71 |
| ▸ | CA9 | Q16790 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL2416723 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL6259045 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL3284185 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL2676112 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL725167 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL5081287 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL10964916 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL377044 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL10961254 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL11822273 | 0.94 | CA1 (0.62) | CA1CA2CA9TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536729-B1 | METHOD FOR FORMING A LASER-SINTERABLE POWDER | 3D SYSTEMS INC (US) | 2020-12-02 | — | — | EP | claimed |
| CN-110240907-A | Etching solution for selectively removing silicon-germanium alloy from silicon-germanium/germanium stack during semiconductor device fabrication | 弗萨姆材料美国有限责任公司 | 2019-09-17 | — | — | CN | claimed |
| EP-2265673-B1 | POWDER COMPOSITIONS AND METHODS OF MANUFACTURING ARTICLES THEREFROM | 3D SYSTEMS INC (US) | 2019-05-08 | — | — | EP | claimed |
| CN-109423291-A | Etching solution for selectively removing silicon-germanium alloy from silicon-germanium/silicon stack in manufacturing semiconductor device | 弗萨姆材料美国有限责任公司 | 2019-03-05 | — | — | CN | claimed |
| CN-108676172-A | A kind of method that liquid phase method synthesizes multiple tooth coordination polymer | 中钢集团洛阳耐火材料研究院有限公司 | 2018-10-19 | — | — | CN | claimed |
| EP-2943796-B1 | IN VITRO METHOD, USE OF AN AGENT AND COLLECTION DEVICE FOR THE INHIBITION OF COAGULATION IN BLOOD | WESER BISSE PETRA (DE) | 2018-05-30 | — | — | EP | claimed |
| EP-2379311-B1 | POLYESTER POWDER COMPOSITIONS, METHODS AND ARTICLES | 3D SYSTEMS INC (US) | 2018-05-30 | — | — | EP | claimed |
| CN-107810239-A | Polyamide composition with high melt flow and good mechanical properties | 巴斯夫欧洲公司 | 2018-03-16 | — | — | CN | claimed |
| CN-107567483-A | The purposes of eutectic | 斯特拉斯克莱德大学 | 2018-01-09 | — | — | CN | claimed |
| CN-103492481-B | Resin combination, prepreg and metal-clad laminate | MITSUBISHI GAS CHEMICAL CO.,INC. (JP) | 2016-04-27 | — | — | CN | claimed |
| CN-1231446-C | Process for producing aromatic carboxylic acid | SAMSUNG ATOFINA CO LTD (KR) | 2005-12-14 | — | — | CN | claimed |
| EP-1173401-B1 | A PRODUCTION METHOD OF AROMATIC CARBOXYLIC ACIDS | SAMSUNG GENERAL CHEMICALS CO (KR) | 2005-05-11 | — | — | EP | claimed |
| EP-1140765-B1 | A PRODUCTION METHOD OF AROMATIC CARBOXYLIC ACIDS | SAMSUNG GENERAL CHEMICALS CO (KR) | 2005-03-30 | — | — | EP | claimed |
| EP-0852009-B1 | BUFFER COMPOSITION FOR REAGENTS FOR IMMUNOASSAY | ABBOTT LAB (US) | 2002-08-28 | — | — | EP | claimed |
| CN-1334792-A | Method for production of aromatic carboxylic acids | SAMSUNG GENERAL CHEMICALS CO (KR) | 2002-02-06 | — | — | CN | claimed |
| CN-1333743-A | Production method of aromatic carboxylic acids | SAMSUNG GENERAL CHEMICALS CO (KR) | 2002-01-30 | — | — | CN | claimed |
| EP-0338916-B1 | HAEMOGLOBIN MACROMOLECULAR COMPLEXES, METHOD OF PREPARATION AND THEIR USES | PASTEUR MERIEUX SERUMS ET VACCINS (FR) | 1992-07-01 | — | — | EP | claimed |
| EP-0096654-B1 | PROCESS FOR SIZING PAPER WITH ANIONIC, HYDROPHOBIC SIZING AGENTS AND CATIONIC RETENTION AGENTS | CIBA-GEIGY AG (CH) | 1987-10-28 | — | — | EP | claimed |
| EP-0154359-B1 | FABRIC CLEANING/CONDITIONING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1987-07-29 | — | — | EP | claimed |
| EP-0096654-A2 | Process for sizing paper with anionic, hydrophobic sizing agents and cationic retention agents | CIBA-GEIGY AG (CH) | 1983-12-21 | — | — | EP | claimed |