Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.71 |
| ▸ | CA2 | P00918 | 3/20 | 0.71 |
| ▸ | CA9 | Q16790 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL2416723 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL6259045 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL3284185 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL2676112 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL1122633 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL725167 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL5081287 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL10964916 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL10961254 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL11822273 | 0.94 | CA1 (0.62) | CA1CA2CA9TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3854774-B1 | METHOD FOR PREPARING ESTER-BASED COMPOSITION | LG CHEMICAL LTD (KR) | 2024-03-20 | — | — | EP | claimed |
| EP-4023335-A1 | METHOD FOR REGENERATING HYDROGENATION CATALYSTS | Evonik Operations GmbH (DE) | 2022-07-06 | — | — | EP | claimed |
| EP-4015079-A1 | METHOD FOR REGENERATING HYDROGENATION CATALYSTS | Evonik Operations GmbH (DE) | 2022-06-22 | — | — | EP | claimed |
| EP-3419957-B1 | AROMATIC COMPOUNDS FROM FURANICS | TNO (NL) | 2021-09-29 | — | — | EP | claimed |
| EP-2716360-B9 | METHOD FOR PREPARING POROUS ORGANIC-INORGANIC HYBRID MATERIALS | KOREA RES INST CHEMICAL TECH (KR) | 2019-03-27 | — | — | EP | claimed |
| EP-2716360-B1 | METHOD FOR PREPARING POROUS ORGANIC-INORGANIC HYBRID MATERIALS | KOREA RES INST CHEMICAL TECH (KR) | 2018-10-31 | — | — | EP | claimed |
| EP-1796745-B1 | POLYMER-BASED TISSUE-ADHESIVE FOR MEDICAL USE | DU PONT (US) | 2011-05-25 | — | — | EP | claimed |
| EP-1570032-B1 | Water blended fuel composition | LUBRIZOL CORP (US) | 2011-02-09 | — | — | EP | claimed |
| EP-1263894-B1 | BARRIER COATINGS USING POLYACIDS, PROCESS FOR OBTAINING THEM AND POLYCARBOXYLATE COATING COMPOSITIONS | DOW CORNING (US) | 2010-01-20 | — | — | EP | claimed |
| EP-1263889-B2 | BARRIER COATINGS HAVING BIS-SILANES | DOW CORNING (US) | 2008-07-23 | — | — | EP | claimed |
| EP-0900235-B1 | FRAGMENTS OF CR1 AND THEIR USE | ADPROTECH LTD (GB) | 2006-07-12 | — | — | EP | claimed |
| EP-1263889-B1 | BARRIER COATINGS HAVING BIS-SILANES | DOW CORNING (US) | 2005-05-04 | — | — | EP | claimed |
| EP-0766716-B1 | WATER-BASED INK COMPOSITIONS AND POLYMERS USEFUL FOR THEIR PREPARATION | STANFORD RES INST INT (US) | 2004-06-23 | — | — | EP | claimed |
| EP-0338916-B1 | HAEMOGLOBIN MACROMOLECULAR COMPLEXES, METHOD OF PREPARATION AND THEIR USES | PASTEUR MERIEUX SERUMS ET VACCINS (FR) | 1992-07-01 | — | — | EP | claimed |
| US-4160311-A | Method of manufacturing a cathode ray tube for displaying colored pictures | U.S. PHILIPS CORPORATION (US) | 1979-07-10 | — | — | US | claimed |
| EP-4023335-A1 | METHOD FOR REGENERATING HYDROGENATION CATALYSTS | Evonik Operations GmbH (DE) | 2022-07-06 | — | — | EP | disclosed |
| EP-4015079-A1 | METHOD FOR REGENERATING HYDROGENATION CATALYSTS | Evonik Operations GmbH (DE) | 2022-06-22 | — | — | EP | disclosed |
| US-4112563-A | Color display tube and method of manufacturing same | U.S. PHILIPS CORPORATION (US) | 1978-09-12 | — | — | US | disclosed |
| US-4107569-A | Color selection means comprising lens electrodes spaced by grains of insulating material | U.S. PHILIPS CORPORATION (US) | 1978-08-15 | — | — | US | disclosed |
| US-4066923-A | Color selection lens electrodes connected by diffusion bonds | U.S. PHILIPS CORPORATION (US) | 1978-01-03 | — | — | US | disclosed |