Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.71 |
| ▸ | CA2 | P00918 | 3/20 | 0.71 |
| ▸ | CA9 | Q16790 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.40 |
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL6259045 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL3284185 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL2676112 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL1122633 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL725167 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL5081287 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL10964916 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL377044 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL10961254 | 1.00 | CA1 (0.71) | CA1CA2CA9TSHRTP53 | |
| Benzene SCHEMBL11822273 | 0.94 | CA1 (0.62) | CA1CA2CA9TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774994-B1 | A CROSSLINKED POLYMER AND RELATED METHODS THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2025-07-30 | — | — | EP | claimed |
| WO-2024146631-A9 | PREPARATION METHOD FOR PARP7 INHIBITOR | 齐鲁制药有限公司 | 2024-08-15 | — | — | WO | claimed |
| WO-2024146631-A1 | PREPARATION METHOD FOR PARP7 INHIBITOR | 齐鲁制药有限公司 | 2024-07-11 | — | — | WO | claimed |
| US-11981774-B2 | Crosslinked polymer and related methods thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2024-05-14 | — | — | US | claimed |
| US-20190031834-A1 | AMPHIPHILIC COPOLYMERS THEIR PREPARATION AND USE FOR THE DELIVERY OF DRUGS | DISTRETTO TECNOLOGICO SICILIA MICRO E NANO SISTEMI S.C.A.R.L. (IT) | 2019-01-31 | — | — | US | claimed |
| EP-3209333-A1 | AMPHIPHILIC COPOLYMERS THEIR PREPARATION AND USE FOR THE DELIVERY OF DRUGS | Distretto Tecnologico Sicilia Micro e Nano Sistemi S.C.A.R.L. (IT) | 2017-08-30 | — | — | EP | claimed |
| WO-2016055111-A1 | AMPHIPHILIC COPOLYMERS THEIR PREPARATION AND USE FOR THE DELIVERY OF DRUGS | DISTRETTO TECNOLOGICO SICILIA MICRO E NANO SISTEMI S.C.A.R.L. (IT) | 2016-04-14 | — | — | WO | claimed |
| US-6984713-B2 | For use in fuel cells, membranes | FuMa-Tech Gesellschaft fur funktionelle Membranen und Anlagentechnologie mbH (DE) | 2006-01-10 | — | — | US | claimed |
| US-20040131910-A1 | For use in fuel cells, membranes | FuMa-Tech Gesellschaft fur funktionelle Membranen und Anlagentechnologie mbH (DE) | 2004-07-08 | — | — | US | claimed |
| JP-7173125-A | — | — | None | — | — | JP | disclosed |
| EP-3774994-B1 | A CROSSLINKED POLYMER AND RELATED METHODS THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2025-07-30 | — | — | EP | disclosed |
| EP-4534607-A1 | RESIN COMPOSITE AND METHOD FOR PRODUCING RESIN COMPOSITE | Nippon Paper Industries Co., Ltd. (JP) | 2025-04-09 | — | — | EP | disclosed |
| US-20250092250-A1 | RESIN COMPOSITION AND METHOD FOR PRODUCING RESIN COMPOSITION | NIPPON PAPER INDUSTRIES CO., LTD. (JP) | 2025-03-20 | — | — | US | disclosed |
| WO-2024146631-A9 | PREPARATION METHOD FOR PARP7 INHIBITOR | 齐鲁制药有限公司 | 2024-08-15 | — | — | WO | disclosed |
| EP-1650253-A1 | FIBER-REINFORCED COMPOSITE MATERIAL, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Kyoto University (JP) | 2006-04-26 | — | — | EP | disclosed |
| US-6984713-B2 | For use in fuel cells, membranes | FuMa-Tech Gesellschaft fur funktionelle Membranen und Anlagentechnologie mbH (DE) | 2006-01-10 | — | — | US | disclosed |
| CN-1580117-A | Medical polyvinyl chloride plastic and its product | SHANGHAI BLOOD TRANSFUSION TEC (CN) | 2005-02-16 | — | — | CN | disclosed |
| US-20040131910-A1 | For use in fuel cells, membranes | FuMa-Tech Gesellschaft fur funktionelle Membranen und Anlagentechnologie mbH (DE) | 2004-07-08 | — | — | US | disclosed |
| CN-2548971-Y | Fluidization conveying for powder of benzene dicarbonic acid and nitrogen gas recovery device | UNIV ZHEJIANG (CN) | 2003-05-07 | — | — | CN | disclosed |
| JP-H07173125-A | BENZENEDICARBOXYLIC ACID AND ITS ESTER AND PRODUCTION THEREOF | NIPPON NOHYAKU CO LTD | 1995-07-11 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031834-A1 | AMPHIPHILIC COPOLYMERS THEIR PREPARATION AND USE FOR THE DELIVERY OF DRUGS | ABCB11, ABCB1, ABCB4 | CA1 4322/4885CA2 4217/4885CA9 3228/4885 |
| US-11981774-B2 | Crosslinked polymer and related methods thereof | PARN, HNRNPU, DPYD | CA1 1221/4885CA2 3498/4885CA9 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.