Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | KDM6A | O15550 | 1/20 | 0.52 |
| ▸ | TET3 | O43151 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | KDM4B | O94953 | 1/20 | 0.52 |
| ▸ | KDM5C | P41229 | 1/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.52 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.52 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113628 | 1.00 | KDM4E (0.59) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL112246 | 1.00 | KDM4E (0.59) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL10155529 | 0.87 | KDM4E (0.64) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL21957194 | 0.85 | KDM4E (0.44) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL21957195 | 0.85 | KDM4E (0.44) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL113922 | 0.83 | BRD4 (0.56) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL114752 | 0.83 | BRD4 (0.56) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL137732 | 0.83 | KDM4E (0.57) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL113761 | 0.83 | BRD4 (0.56) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL113637 | 0.83 | KDM4E (0.57) | KDM4EL3MBTL1HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2012-03-08 | — | — | US | disclosed |
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2012-03-08 | — | — | US | disclosed |
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2012-03-08 | — | — | US | disclosed |
| US-8058442-B2 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2011-11-15 | — | — | US | disclosed |
| US-8058442-B2 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2011-11-15 | — | — | US | disclosed |
| US-8058442-B2 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2011-11-15 | — | — | US | disclosed |
| US-20060234927-A1 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | FECH, HMOX1, FTH1 | KDM4E 3494/4885L3MBTL1 908/4885HTT 9/4885 |
| US-20060234927-A1 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | FECH, HMOX1, FTH1 | KDM4E 3557/4885L3MBTL1 1041/4885HTT 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.