SCHEMBL11227007

SCHEMBL11227007

COc1ccc2c(c1)n[c]n2Cc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.55
HTT P42858 2/20 0.55
POLB P06746 2/20 0.55
FGFR1 P11362 1/20 0.45
SIGMAR1 Q99720 2/20 0.43
MAPT P10636 3/20 0.43
KMT2A Q03164 3/20 0.43
TP53 P04637 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HPGD P15428 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
PLA2G2A P14555 4/20 0.42
PLA2G1B P04054 1/20 0.42
HTR6 P50406 1/20 0.42
LMNA P02545 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2541667 0.83 HTT (0.52) ALDH1A1HTTSIGMAR1MAPTKMT2A
SCHEMBL7805184 0.81 TDP1 (0.51) ALDH1A1HTTPOLBFGFR1MAPT
SCHEMBL7815068 0.80 TDP1 (0.47) ALDH1A1HTTPOLBFGFR1MAPT
SCHEMBL28770439 0.80 TDP1 (0.44) ALDH1A1HTTPOLBFGFR1SIGMAR1
SCHEMBL28770562 0.78 NPC1 (0.43) ALDH1A1HTTMAPTKMT2ASMN1; SMN2
SCHEMBL7814439 0.77 TDP1 (0.41) ALDH1A1HTTPOLBFGFR1KMT2A
SCHEMBL6047768 0.73 CYP11B1 (0.60) ALDH1A1HTTPOLBFGFR1SMN1; SMN2
SCHEMBL19911510 0.73 HCAR3 (0.65) ALDH1A1HTTPOLBFGFR1KDM4E
SCHEMBL27974787 0.73 TNF (0.44) ALDH1A1HTTMAPTKMT2ASMN1; SMN2
SCHEMBL3652546 0.72 TDP1 (0.44) ALDH1A1HTTPOLBFGFR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4326065-A PLASTICS, VARNISHES, POLYESTERS EASTMAN KODAK COMPANY (US) 1982-04-20 US disclosed
US-4251433-A BENZOTRIAZOLE DERIVATIVES; FOR POLYMERS EASTMAN KODAK COMPANY (US) 1981-02-17 US disclosed
US-4236013-A ADDITIVES FOR POLYMERS EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4172081-A Benzotriazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-10-23 US disclosed
US-4162254-A Benzoxazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-07-24 US disclosed
US-4137235-A ULTRAVIOLET STABILIZERS IN POLYMERIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1979-01-30 US disclosed
US-4116928-A Heterocylic ester, ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4116929-A POLYESTERS EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4096115-A Ultraviolet light stabilized polymers EASTMAN KODAK COMPANY (US) 1978-06-20 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4017508-A POLYMERS EASTMAN KODAK COMPANY (US) 1977-04-12 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed