Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805184 | 0.89 | TDP1 (0.51) | TDP1ALDH1A1SMN1; SMN2HTR6FGFR1 | |
| SCHEMBL7804842 | 0.88 | DYRK1A (0.42) | TDP1ALDH1A1SMN1; SMN2DYRK1AKDM4E | |
| SCHEMBL7810877 | 0.85 | FGFR1 (0.49) | ALDH1A1FGFR1MAPT | |
| SCHEMBL7814439 | 0.82 | TDP1 (0.41) | TDP1ALDH1A1SMN1; SMN2FGFR1KDM4E | |
| SCHEMBL3652546 | 0.80 | TDP1 (0.44) | TDP1ALDH1A1SMN1; SMN2FGFR1KDM4E | |
| SCHEMBL11227007 | 0.80 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2HTR6FGFR1KDM4E | |
| SCHEMBL7821616 | 0.76 | TDP1 (0.44) | TDP1ALDH1A1SMN1; SMN2DYRK1AKDM4E | |
| SCHEMBL1828029 | 0.75 | SLC9A1 (0.47) | TDP1ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL7811008 | 0.73 | TDP1 (0.41) | TDP1ALDH1A1SMN1; SMN2FGFR1KDM4E | |
| SCHEMBL7815075 | 0.73 | FGFR1 (0.43) | ALDH1A1FGFR1ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |