Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815068 | 0.89 | TDP1 (0.47) | TDP1POLBNPSR1RPS6KA5FGFR1 | |
| SCHEMBL7821616 | 0.87 | TDP1 (0.44) | TDP1POLBNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7814439 | 0.83 | TDP1 (0.41) | TDP1POLBFGFR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11227007 | 0.81 | ALDH1A1 (0.55) | POLBNPSR1FGFR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3652546 | 0.78 | TDP1 (0.44) | TDP1POLBFGFR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17187279 | 0.77 | KDM4E (0.39) | RPS6KA5ALDH1A1HTTMAPTKDM4E | |
| SCHEMBL27787868 | 0.77 | ALDH1A1 (0.34) | NPSR1ALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL5982432 | 0.77 | PGK1 (0.39) | TDP1FGFR1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7804842 | 0.76 | DYRK1A (0.42) | TDP1POLBNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7811008 | 0.74 | TDP1 (0.41) | TDP1POLBFGFR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |