Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.37 |
| ▸ | BRD1 | O95696 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1123020 | 0.80 | BRD4 (0.41) | BRD4SRCBRPF1BRD1MAPK1 | |
| SCHEMBL10400222 | 0.72 | BIRC5 (0.47) | F10GRM1 | |
| SCHEMBL7264816 | 0.68 | EGFR (0.38) | F10MAPK1GRM1 | |
| SCHEMBL23902683 | 0.67 | EPHX2 (0.44) | — | |
| SCHEMBL30241420 | 0.67 | EPHX2 (0.44) | — | |
| SCHEMBL1728508 | 0.66 | GRM1 (0.41) | F10MAPK1GRM1 | |
| SCHEMBL21968162 | 0.64 | BRD4 (0.72) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21905013 | 0.63 | BRD4 (1.00) | BRD4BRD2BRD3BRDT | |
| SCHEMBL140918 | 0.62 | ROCK2 (0.47) | MAPK1 | |
| SCHEMBL27741182 | 0.62 | BIRC5 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |