Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 5/20 | 0.39 |
| ▸ | BRD1 | O95696 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.36 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.35 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122795 | 0.80 | BRD4 (0.46) | BRD4SRCMAPK1BRPF1BRD1 | |
| SCHEMBL1122752 | 0.72 | SRC (0.37) | BRD4SRCLRRK2 | |
| SCHEMBL9179590 | 0.69 | TGM2 (0.59) | BRD4SRCMAPK1TEAD4TGM2 | |
| SCHEMBL18437810 | 0.68 | BRD4 (0.44) | BRD4SRCLRRK2 | |
| SCHEMBL18437814 | 0.68 | BRD4 (0.44) | BRD4SRCLRRK2 | |
| SCHEMBL7259187 | 0.66 | EGFR (0.36) | — | |
| SCHEMBL1122446 | 0.61 | ALDH1A1 (0.63) | MAPK1 | |
| SCHEMBL20782676 | 0.61 | PDE10A (0.43) | SRCPKM | |
| SCHEMBL18437729 | 0.61 | PTGS2 (0.47) | — | |
| SCHEMBL6343382 | 0.60 | PKM (0.61) | BRD4BRPF1BRD1PKMBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |