SCHEMBL11228111

SCHEMBL11228111

CCn1[c]nc2ccc(C#N)cc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACSS2 Q9NR19 1/20 0.42
CYP11B2 P19099 7/20 0.41
CYP11B1 P15538 4/20 0.41
CYP2A6 P11509 2/20 0.38
DAPK3 O43293 1/20 0.34
MAP4K4 O95819 1/20 0.34
PRKACA P17612 1/20 0.34
LTK P29376 1/20 0.34
MAPK8 P45983 1/20 0.34
CSNK1A1 P48729 1/20 0.34
CDK8 P49336 1/20 0.34
CLK2 P49760 1/20 0.34
CDK9 P50750 1/20 0.34
LIMK1 P53667 1/20 0.34
CDK5 Q00535 1/20 0.34
MAP2K1 Q02750 1/20 0.34
LRRK2 Q5S007 1/20 0.34
AURKB Q96GD4 1/20 0.34
CLK4 Q9HAZ1 1/20 0.34
ALK Q9UM73 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17187180 0.76 PTPN1 (0.40) ACSS2ALDH1A1PTGER4KDM4EGLA
SCHEMBL7821616 0.73 TDP1 (0.44) ACSS2ALDH1A1PTGER4KDM4E
SCHEMBL11331901 0.70 BRD4 (0.49) ACSS2CYP11B2CYP11B1IDO1KCNH2
SCHEMBL6187558 0.70 SLC9A1 (0.53) ACSS2CYP11B2CYP11B1CYP2A6KDM4E
SCHEMBL29526943 0.68 ACSS2 (0.56) ACSS2CYP11B2CYP11B1CYP2A6DAPK3
SCHEMBL26181299 0.68 ACSS2 (0.56) ACSS2CYP11B2CYP11B1CYP2A6DAPK3
SCHEMBL21076085 0.66 PTGER4 (0.48) ACSS2CYP11B2CYP11B1CYP2A6PTGER4
SCHEMBL5982432 0.66 PGK1 (0.39) ALDH1A1KDM4EGLA
SCHEMBL28971006 0.66 KDM4E (0.59) ACSS2CYP11B2CYP11B1ALDH1A1PTGER4
SCHEMBL19848088 0.65 BRD4 (0.45) IDO1KCNH2BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4326065-A PLASTICS, VARNISHES, POLYESTERS EASTMAN KODAK COMPANY (US) 1982-04-20 US disclosed
US-4251433-A BENZOTRIAZOLE DERIVATIVES; FOR POLYMERS EASTMAN KODAK COMPANY (US) 1981-02-17 US disclosed
US-4236013-A ADDITIVES FOR POLYMERS EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4172081-A Benzotriazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-10-23 US disclosed
US-4162254-A Benzoxazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-07-24 US disclosed
US-4137235-A ULTRAVIOLET STABILIZERS IN POLYMERIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1979-01-30 US disclosed
US-4116928-A Heterocylic ester, ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4116929-A POLYESTERS EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4096115-A Ultraviolet light stabilized polymers EASTMAN KODAK COMPANY (US) 1978-06-20 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4017508-A POLYMERS EASTMAN KODAK COMPANY (US) 1977-04-12 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed