Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.49 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | PPM1D | O15297 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2812600 | 0.90 | KMT2A (0.56) | KMT2AMEN1SRD5A2GRIK1ALDH1A1 | |
| SCHEMBL25909564 | 0.84 | KMT2A (0.52) | KMT2AMEN1ALDH1A1EPHX1HDAC6 | |
| SCHEMBL31276700 | 0.84 | KMT2A (0.52) | KMT2AMEN1ALDH1A1EPHX1HDAC6 | |
| SCHEMBL11190532 | 0.84 | PTPRC (0.46) | KMT2AMEN1HDAC6CHEK2GAA | |
| SCHEMBL11180540 | 0.84 | KMT2A (0.52) | KMT2AMEN1ALDH1A1EPHX1HDAC6 | |
| SCHEMBL27528076 | 0.82 | KMT2A (0.54) | KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL11590207 | 0.82 | GRIK1 (0.53) | KMT2AMEN1GRIK1ALDH1A1GAA | |
| SCHEMBL13687812 | 0.82 | KMT2A (0.50) | KMT2AMEN1GRIK1ALDH1A1GAA | |
| SCHEMBL6260511 | 0.82 | GBA1 (0.62) | KMT2AMEN1GRIK1ALDH1A1GAA | |
| SCHEMBL27979790 | 0.82 | KMT2A (0.50) | KMT2AMEN1GRIK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57176943-A | — | — | None | — | — | JP | disclosed |
| JP-56158751-A | — | — | None | — | — | JP | disclosed |
| US-9650352-B2 | Use of (2R, 6R)-hydroxynorketamine, (S)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (R,S)-ketamine in the treatment of depression and neuropathic pain | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-05-16 | — | — | US | disclosed |
| US-9650352-B2 | Use of (2R, 6R)-hydroxynorketamine, (S)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (R,S)-ketamine in the treatment of depression and neuropathic pain | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-05-16 | — | — | US | disclosed |
| US-8912201-B2 | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20140296241-A1 | THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2014-10-02 | — | — | US | disclosed |
| US-20140296241-A1 | THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2014-10-02 | — | — | US | disclosed |
| JP-S57176943-A | 4-(TRANS-4'-ALKYLCYCLOHEXYLMETHYLOXY)BENZOIC ACID 3\"- CHLORO-4\"-CYANOPHENYL ESTER | CHISSO CORP | 1982-10-30 | — | — | JP | disclosed |
| JP-S56158751-A | 4\"-CYANOPHENYL 4-(TRANS-4'-ALKYLCYCLOHEXYLMETHOXY)BENZOATE | CHISSO CORP | 1981-12-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296241-A1 | THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN | CYP2D6, OPRK1, CYP2S1 | KMT2A 1750/4885MEN1 4765/4885SRD5A2 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.