Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 7/20 | 0.38 |
| ▸ | TTK | P33981 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11228272 | 1.00 | MKNK1 (0.39) | MKNK1MKNK2ITKTTKAURKB | |
| SCHEMBL11224738 | 0.82 | ITK (0.42) | MKNK1MKNK2ITKTTKAURKB | |
| SCHEMBL11224734 | 0.82 | ITK (0.42) | MKNK1MKNK2ITKTTKAURKB | |
| SCHEMBL11251113 | 0.82 | TTK (0.42) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11251128 | 0.82 | TTK (0.42) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11229145 | 0.80 | TTK (0.51) | MKNK1MKNK2ITKTTKAURKB | |
| SCHEMBL11229132 | 0.80 | TTK (0.51) | MKNK1MKNK2ITKTTKAURKB | |
| SCHEMBL11222397 | 0.79 | ITK (0.55) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11222394 | 0.79 | ITK (0.55) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL11223826 | 0.76 | ITK (0.39) | ITKTTKAURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |