Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LIG1 | P18858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19816955 | 0.80 | TSHR (0.44) | TSHRHSD17B10HPGDMAPK1LIG1 | |
| SCHEMBL9671334 | 0.79 | TSHR (0.45) | TSHRHSD17B10HPGDMAPK1LIG1 | |
| SCHEMBL4608367 | 0.78 | ALDH1A1 (0.55) | TSHRHSD17B10HPGDMAPK1LIG1 | |
| SCHEMBL26118236 | 0.76 | TSHR (0.53) | TSHRHSD17B10HPGDMAPK1LIG1 | |
| SCHEMBL12004979 | 0.76 | TSHR (0.42) | TSHRHSD17B10HPGDMAPK1LIG1 | |
| SCHEMBL20554725 | 0.76 | CYP3A4 (0.49) | TSHRHSD17B10HPGDMAPK1LIG1 | |
| SCHEMBL20554231 | 0.75 | TSHR (0.45) | TSHRHSD17B10HPGDMAPK1LIG1 | |
| SCHEMBL1374548 | 0.74 | ALDH1A1 (0.56) | TSHRHSD17B10HPGDMAPK1ALDH1A1 | |
| SCHEMBL30873744 | 0.74 | ALDH1A1 (0.56) | TSHRHSD17B10HPGDMAPK1ALDH1A1 | |
| SCHEMBL27592055 | 0.74 | HPGD (0.47) | TSHRHSD17B10HPGDMAPK1LIG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4310527-A | DISORDERS OF CAROIAC RHYTHM AND CORONARY HEART DISEASES AND HYDPERTENSION | CIBA-GEIGY CORPORATION (US) | 1982-01-12 | — | — | US | disclosed |
| US-4140789-A | ADRENERGIC BLOCKING AGENTS, CARDIOTONIC, ANTIARRHYTHMIA, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1979-02-20 | — | — | US | disclosed |