Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 2/20 | 0.57 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.54 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.54 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.54 |
| ▸ | SHBG | P04278 | 7/20 | 0.67 |
| ▸ | LMNA | P02545 | 8/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.57 |
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.57 |
| ▸ | SNCA | P37840 | 4/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.57 |
| ▸ | PGR | P06401 | 3/20 | 0.57 |
| ▸ | AR | P10275 | 3/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11209693 | 0.93 | SHBG (0.77) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL11209689 | 0.93 | SHBG (0.77) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL11228601 | 0.82 | SHBG (0.58) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL1900826 | 0.81 | SHBG (1.00) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL1899372 | 0.81 | SHBG (1.00) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL1899376 | 0.81 | SHBG (1.00) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL4102861 | 0.81 | SHBG (1.00) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL13752654 | 0.81 | SHBG (1.00) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL4102864 | 0.81 | SHBG (1.00) | SHBGLMNACYP3A4HSD17B10SERPINA6 | |
| SCHEMBL572119 | 0.79 | SHBG (0.77) | SHBGLMNACYP3A4HSD17B10SERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4330539-A | Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof | AKZO NV (NL) | 1982-05-18 | — | — | US | claimed |