SCHEMBL11228708

SCHEMBL11228708

O=C(O)c1cccc(C(=O)Oc2ccccc2Cl)c1-c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTK2B Q14289 1/20 0.54
FABP4 P15090 6/20 0.50
FABP3 P05413 5/20 0.50
FABP5 Q01469 2/20 0.50
ESR1 P03372 2/20 0.49
ESR2 Q92731 1/20 0.49
KDM4E B2RXH2 3/20 0.49
HSD17B10 Q99714 3/20 0.49
ALDH1A1 P00352 3/20 0.49
HPGD P15428 3/20 0.49
TP53 P04637 2/20 0.48
HTT P42858 1/20 0.48
LMNA P02545 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48
NPSR1 Q6W5P4 1/20 0.45
TSHR P16473 2/20 0.45
ITGB3 P05106 1/20 0.41
ITGA2B P08514 1/20 0.41
HMGB1 P09429 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11228704 0.95 PTK2B (0.57) PTK2BFABP4FABP3FABP5ESR1
SCHEMBL7081862 0.87 PTK2B (0.52) PTK2BESR1ESR2KDM4EHSD17B10
SCHEMBL11223717 0.84 FABP4 (0.52) FABP4FABP3FABP5KDM4EHSD17B10
SCHEMBL10602875 0.81 PTK2B (0.70) PTK2BESR1ESR2KDM4EHSD17B10
SCHEMBL9241781 0.80 MAPT (0.57) FABP4FABP3FABP5KDM4EHSD17B10
SCHEMBL11235067 0.79 FABP4 (0.53) FABP4FABP3FABP5ESR1KDM4E
SCHEMBL11223714 0.79 FABP3 (0.49) FABP4FABP3KDM4EHSD17B10LMNA
SCHEMBL7528413 0.79 FABP3 (0.68) FABP4FABP3FABP5KDM4EALDH1A1
SCHEMBL31037493 0.79 FABP3 (0.68) FABP4FABP3FABP5KDM4EALDH1A1
SCHEMBL11714257 0.77 HNF4A (0.52) FABP4FABP3FABP5KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4329443-A Process for polyester-carbonate transesterifications GENERAL ELECTRIC COMPANY (US) 1982-05-11 US disclosed