Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 11/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11221868 | 0.77 | CA12 (0.49) | MAPTCA12CA1CA2CA3 | |
| SCHEMBL11086488 | 0.75 | CA2 (0.44) | MAPTCA1CA2ACEACE2 | |
| SCHEMBL11084531 | 0.75 | CA2 (0.44) | MAPTCA1CA2KMT2AACE | |
| SCHEMBL11084537 | 0.75 | CA2 (0.44) | MAPTCA1CA2KMT2AACE | |
| SCHEMBL11086491 | 0.75 | CA2 (0.44) | MAPTCA1CA2ACEACE2 | |
| Lisinopril Anhydrous SCHEMBL17105874 | 0.74 | ACE (0.61) | MAPTCA12CA1CA2CA3 | |
| SCHEMBL11090981 | 0.70 | ACE (0.43) | MAPTCA12CA1CA2CA3 | |
| SCHEMBL11090985 | 0.70 | ACE (0.43) | MAPTCA12CA1CA2CA3 | |
| SCHEMBL3718797 | 0.68 | ACE (0.51) | MAPTACEACE2RENKDM4E | |
| Chlorthalidone SCHEMBL29127388 | 0.68 | CA1 (0.84) | MAPTCA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312809-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1982-01-26 | — | — | US | disclosed |