SCHEMBL11228850

SCHEMBL11228850

CC(=O)Nc1ccc(SC#N)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.51
MAPT P10636 4/20 0.51
GFER P55789 1/20 0.51
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA9 Q16790 1/20 0.49
KDM4E B2RXH2 2/20 0.42
HSD17B10 Q99714 1/20 0.42
DHODH Q02127 4/20 0.41
HPGD P15428 4/20 0.40
LMNA P02545 2/20 0.40
NPC1 O15118 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
USP2 O75604 1/20 0.40
GAA P10253 1/20 0.40
PDK1 Q15118 1/20 0.39
PDK2 Q15119 1/20 0.39
PDK3 Q15120 1/20 0.39
PDK4 Q16654 1/20 0.39
POLB P06746 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3625952 0.81 CA1 (0.54) ALDH1A1MAPTCA1CA2CA9
SCHEMBL3407800 0.79 ALDH1A1 (0.49) ALDH1A1MAPTGFERSMN1; SMN2GAA
SCHEMBL6347537 0.79 PDK1 (0.68) PDK1PDK2PDK3PDK4
SCHEMBL10828000 0.77 MAPT (0.56) ALDH1A1MAPTGFERHPGDLMNA
SCHEMBL3618880 0.77 CA1 (0.50) ALDH1A1MAPTCA1CA2CA9
SCHEMBL31500548 0.77 CA1 (0.50) ALDH1A1MAPTCA1CA2CA9
SCHEMBL9658598 0.76 PDK1 (0.62) ALDH1A1MAPTCA1CA2CA9
SCHEMBL3625424 0.76 CA1 (0.49) ALDH1A1CA1CA2CA9KDM4E
SCHEMBL134187 0.75 ALDH1A1 (0.47) ALDH1A1MAPTGFERCA2KDM4E
SCHEMBL20817443 0.74 POLB (0.58) ALDH1A1KDM4EHSD17B10LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4349378-A Compounds useful as pesticides FBC LIMITED (GB) 1982-09-14 US disclosed
US-4309559-A PLANT GROWTH REGULATORS AND ESPECIALLY FUNGICIDES OR HERBICIDES FBC LIMITED (GB) 1982-01-05 US disclosed