Bromide

Bromide

SCHEMBL11229202

Br.O=C1c2ccc(O)cc2OCC1n1ccnc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 9/20 0.47
MAOA P21397 2/20 0.40
MAOB P27338 2/20 0.40
ESR2 Q92731 2/20 0.36
ALOX12 P18054 1/20 0.36
ESR1 P03372 1/20 0.36
MIF P14174 2/20 0.34
CYP17A1 P05093 1/20 0.34
PTPN1 P18031 2/20 0.34
TUBB4A P04350 1/20 0.33
TUBB P07437 1/20 0.33
YES1 P07947 1/20 0.33
TUBA3C P0DPH7 1/20 0.33
TUBA1B P68363 1/20 0.33
TUBA4A P68366 1/20 0.33
TUBB4B P68371 1/20 0.33
TUBB3 Q13509 1/20 0.33
TUBB2A Q13885 1/20 0.33
TUBB8 Q3ZCM7 1/20 0.33
TUBA3E Q6PEY2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11231221 0.99 CYP19A1 (0.48) CYP19A1MAOAMAOBESR2ALOX12
Bromide SCHEMBL11239402 0.91 CYP19A1 (0.44) CYP19A1MAOAMAOBALOX12ESR1
SCHEMBL11231299 0.90 CYP19A1 (0.45) CYP19A1MAOAMAOBALOX12ESR1
SCHEMBL11229062 0.84 CYP19A1 (0.38) CYP19A1CYP17A1PTPN1
SCHEMBL11226045 0.84 CYP19A1 (0.40) CYP19A1MAOBCYP17A1
SCHEMBL9529868 0.82 CYP19A1 (0.48) CYP19A1MAOB
SCHEMBL11237282 0.81 CYP19A1 (0.37) CYP19A1ALOX12
SCHEMBL11230668 0.81 CYP19A1 (0.51) CYP19A1MAOBALOX12PTPN1
Hydrochloric Acid SCHEMBL11221160 0.81 CYP19A1 (0.36) CYP19A1ALOX12
SCHEMBL11233256 0.81 CYP17A1 (0.40) CYP19A1CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4342775-A FOR USE AS ANTICOAGULANT AND REDUCING SERUM SHOLESTEROL OR SERUM TRIGLYCERIDES FARMITALIA CARLO ERBA S.P.A. (IT) 1982-08-03 US disclosed