Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8055545 | 0.80 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL30427027 | 0.80 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL21737038 | 0.78 | — | — | |
| SCHEMBL17470924 | 0.78 | GABRP (0.38) | — | |
| SCHEMBL11223672 | 0.78 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL12791498 | 0.77 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL23250599 | 0.74 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL8055301 | 0.74 | CCR4 (0.35) | CCR4EDNRA | |
| SCHEMBL29862850 | 0.74 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL11223843 | 0.72 | CCR4 (0.35) | CCR4EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4343802-A | ADRENERGIC BLOCKING, ANTIARRYHYTHMIA, AND CARDIOTONIC AGENTS | MERCK, SHARP & DOHME (I.A.) CORP. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4193995-A | B-ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1980-03-18 | — | — | US | disclosed |
| US-4042586-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1977-08-16 | — | — | US | disclosed |
| US-3946009-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1976-03-23 | — | — | US | disclosed |