Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27501035 | 0.77 | CCR4 (0.33) | CCR4EDNRA | |
| SCHEMBL8055545 | 0.76 | CCR4 (0.38) | CCR4TDP1EDNRA | |
| SCHEMBL30427027 | 0.76 | CCR4 (0.38) | CCR4TDP1EDNRA | |
| SCHEMBL11229329 | 0.74 | CCR4 (0.39) | CCR4EDNRA | |
| SCHEMBL11223843 | 0.73 | CCR4 (0.35) | CCR4EDNRA | |
| SCHEMBL11223672 | 0.71 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL10271758 | 0.68 | CCR4 (0.40) | CCR4EDNRA | |
| SCHEMBL23250599 | 0.67 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL29862850 | 0.67 | CCR4 (0.38) | CCR4EDNRA | |
| SCHEMBL7418341 | 0.66 | HTT (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6083951-A | FOR THE TREATMENT OF DISEASES OR MEDICAL CONDITIONS SUCH AS HYPERTENSION, PULMONARY HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |