Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853168 | 0.87 | ALDH1A1 (0.58) | ALDH1A1CYP1A2CYP3A4ALKCYP2D6 | |
| SCHEMBL4432138 | 0.85 | TP53 (0.54) | CYP1A2KMT2ARXFP1PIM1CHEK1 | |
| SCHEMBL11242946 | 0.85 | CYP2D6 (0.53) | ALDH1A1CYP1A2CYP3A4ALKCYP2D6 | |
| SCHEMBL11246270 | 0.84 | CASP1 (0.54) | PKN1PKN2 | |
| SCHEMBL2851890 | 0.81 | ALDH1A1 (0.61) | ALDH1A1CYP1A2CYP3A4ALKCYP2D6 | |
| SCHEMBL4428979 | 0.79 | ALK (0.53) | ALDH1A1CYP1A2CYP3A4ALKCYP2D6 | |
| SCHEMBL11245286 | 0.79 | CYP1A2 (0.63) | ALDH1A1CYP1A2CYP3A4ALKCYP2D6 | |
| SCHEMBL11237850 | 0.79 | PRMT5 (0.43) | ALKMKNK1MKNK2PRMT5WDR77 | |
| SCHEMBL10710552 | 0.77 | AURKA (0.65) | MKNK1MKNK2KMT2ARXFP1PKN1 | |
| SCHEMBL11078693 | 0.75 | MKNK1 (0.56) | CYP1A2CYP3A4ALKCYP2C19MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |