SCHEMBL11229592

SCHEMBL11229592

OCCOCCC1OCCCc2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
KMT2A Q03164 3/20 0.39
LMNA P02545 1/20 0.39
HTR1A P08908 2/20 0.38
DRD2 P14416 2/20 0.38
DRD4 P21917 2/20 0.38
HTR2A P28223 2/20 0.38
HTR1D P28221 1/20 0.38
GAA P10253 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38
DRD1 P21728 1/20 0.38
ADRA1D P25100 1/20 0.38
ADRA1A P35348 1/20 0.38
ADRA1B P35368 1/20 0.38
DRD3 P35462 1/20 0.38
HTR2B P41595 1/20 0.38
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11223852 0.88 ALDH1A1 (0.40) ALDH1A1KMT2ALMNAGAAL3MBTL1
SCHEMBL11552330 0.86 ALDH1A1 (0.44) ALDH1A1KMT2ALMNAHTR1ADRD2
SCHEMBL11220205 0.80 ALDH1A1 (0.45) ALDH1A1KMT2ALMNAHTR1ADRD2
SCHEMBL11255728 0.79 DRD2 (0.39) ALDH1A1KMT2ALMNAHTR1ADRD2
SCHEMBL20906645 0.76 ALDH1A1 (0.52) ALDH1A1KMT2ALMNAHTR1ADRD2
SCHEMBL6640390 0.76 ALDH1A1 (0.52) ALDH1A1KMT2ALMNAHTR1ADRD2
SCHEMBL8859025 0.75 HTR2A (0.49) KMT2ADRD2HTR2AADRA2BADRA2C
SCHEMBL11232660 0.74 ALDH1A1 (0.39) ALDH1A1KMT2ALMNAHTR1ADRD2
SCHEMBL20921224 0.74 ALDH1A1 (0.50) ALDH1A1KMT2ALMNAHTR1ADRD2
SCHEMBL7398195 0.74 ALDH1A1 (0.50) ALDH1A1KMT2ALMNAHTR1ADRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4352805-A BENZOXEPINE DERIVATIVES THE UPJOHN COMPANY (US) 1982-10-05 US disclosed
US-4312868-A HYPOTENSIVE, ANTIPSYCHOTIC THE UPJOHN COMPANY (US) 1982-01-26 US disclosed
US-4251526-A HYPOTENSIVE AGENTS AND ANTIPSYCHOTIC PHARMACIA & UPJOHN COMPANY 1981-02-17 US disclosed
US-4250175-A HYPOTENSIVE AGENTS, ANTIDEPRESSANTS PHARMACIA & UPJOHN COMPANY 1981-02-10 US disclosed
US-4250181-A HYPOTENSIVE AGENTS, ANTIDEPRESSANTS THE UPJOHN COMPANY (US) 1981-02-10 US disclosed
US-4247553-A HYPOTENSIVE AGENTS, ANTIDEPRESSANTS THE UPJOHN COMPANY (US) 1981-01-27 US disclosed
US-4207239-A HYPOTENSIVE, ANTIPSYCHOTIC THE UPJOHN COMPANY (US) 1980-06-10 US disclosed
US-4206123-A INTERMEDIATES FOR HYPOTENSIVES MCCALL JOHN M (US) 1980-06-03 US disclosed
US-4181665-A INTERMEDIATES FOR AMINO DERIVATIVES POSSESSING HYPOTENSIVE AND CENTRAL NERVOUS SYSTEM ACTIVITY THE UPJOHN COMPANY (US) 1980-01-01 US disclosed
US-4179510-A ISOCHROMANS AND 2-BENZOXEPINS THE UPJOHN COMPANY (US) 1979-12-18 US disclosed
US-4153612-A 2-Benzoxepins THE UPJOHN COMPANY (US) 1979-05-08 US disclosed