Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050306 | 0.86 | POLB (0.55) | TSHRPOLBGAAALDH1A1RECQL | |
| SCHEMBL11118433 | 0.85 | ALDH1A1 (0.50) | TSHRPOLBGAAALDH1A1RECQL | |
| SCHEMBL8688272 | 0.84 | HTT (0.62) | TSHRPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL2125979 | 0.84 | ALDH1A1 (0.65) | TSHRPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL11295591 | 0.83 | HTT (0.45) | GAAALDH1A1HPGDFLT1FLT4 | |
| SCHEMBL7965902 | 0.82 | ALDH1A1 (0.59) | TSHRPOLBGAAALDH1A1RECQL | |
| SCHEMBL10850438 | 0.81 | ALDH1A1 (0.67) | TSHRPOLBALDH1A1RECQLTDP1 | |
| SCHEMBL5569924 | 0.81 | MEN1 (0.51) | TSHRALDH1A1RECQLTDP1ALOX15 | |
| SCHEMBL6744997 | 0.81 | TSHR (0.51) | TSHRPOLBGAAALDH1A1RECQL | |
| SCHEMBL7447640 | 0.81 | ABL1 (0.56) | TSHRPOLBGAAALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344957-A | Benz-acyl-benzimidazole derivatives and antiallergic compositions | CIBA-GEIGY CORPORATION (US) | 1982-08-17 | — | — | US | disclosed |
| EP-0000574-B1 | BENZIMIDAZOLE-2 DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS | CIBA-GEIGY AG (CH) | 1982-08-04 | — | — | EP | disclosed |
| US-4323688-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1982-04-06 | — | — | US | disclosed |
| US-4213993-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1980-07-22 | — | — | US | disclosed |
| US-4141982-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1979-02-27 | — | — | US | disclosed |
| EP-0000574-A1 | Benzimidazole-2 derivatives, their preparation and their use for the preparation of medicaments | CIBA-GEIGY AG (CH) | 1979-02-07 | — | — | EP | disclosed |