Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241138 | 0.84 | GRIA1 (0.42) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL11235391 | 0.83 | GAA (0.35) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL11232208 | 0.79 | PKN1 (0.44) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL11229699 | 0.76 | PDE3B (0.43) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL11375997 | 0.72 | GPR35 (0.47) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6679480 | 0.72 | KDM4E (0.50) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL18160498 | 0.72 | ALDH1A1 (0.49) | MAPTCYP3A4TSHRLMNAHPGD | |
| SCHEMBL11231235 | 0.71 | CYP11B1 (0.46) | MAPTCYP3A4CYP1A2ALDH1A1MEN1 | |
| SCHEMBL11237623 | 0.70 | HSD17B10 (0.36) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL11266563 | 0.70 | MAPT (0.49) | MAPTTSHRLMNAHPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |