Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BMP4 | P12644 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226000 | 0.80 | GSK3B (0.49) | DYRK1ANFATC1GSK3BPDGFRBPDGFRA | |
| SCHEMBL11232136 | 0.79 | LATS1 (0.38) | DYRK1ANFATC1GSK3BPDGFRBPDGFRA | |
| SCHEMBL11225309 | 0.78 | NR1D1 (0.39) | GSK3BPDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11238992 | 0.78 | NR1D1 (0.36) | GSK3BPDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11252715 | 0.78 | LATS1 (0.36) | GSK3BCYP3A4KDM4EALDH1A1MAPT | |
| SCHEMBL11229298 | 0.77 | LATS1 (0.40) | GSK3BPDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11237364 | 0.77 | NR1D1 (0.38) | GSK3BPDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11231365 | 0.77 | MAPT (0.43) | GSK3BPDGFRBPDGFRACYP3A4KDM4E | |
| SCHEMBL11226073 | 0.74 | ATM (0.45) | GSK3BKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL11234009 | 0.73 | GSK3B (0.47) | DYRK1ANFATC1GSK3BPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |