Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244896 | 0.86 | GSK3B (0.49) | GSK3BCHEK2MAPK1PIK3CANTRK1 | |
| SCHEMBL11360775 | 0.84 | GSK3B (0.45) | GSK3BCHEK2DYRK1APIK3CANTRK1 | |
| SCHEMBL11222259 | 0.82 | GSK3B (0.76) | GSK3BCHEK2DYRK1APIK3CANTRK1 | |
| SCHEMBL11235819 | 0.81 | CYP2C9 (0.38) | GSK3BMAPK1DYRK1AEGFRPDGFRB | |
| SCHEMBL11237181 | 0.80 | GSK3B (0.46) | GSK3BMAPK1MKNK1MKNK2 | |
| SCHEMBL11245877 | 0.78 | GSK3B (0.45) | GSK3BMAPK1PIK3CAFYNEGFR | |
| SCHEMBL11126827 | 0.76 | HDAC8 (0.48) | GSK3BCHEK2MAPK1DYRK1AAKT2 | |
| SCHEMBL11236404 | 0.75 | GSK3B (0.42) | GSK3BMAPK1CYP2A6CYP11B2 | |
| SCHEMBL11380999 | 0.75 | PRMT5 (0.42) | GSK3BCHEK2DYRK1APIK3CANTRK1 | |
| SCHEMBL11229632 | 0.73 | GSK3B (0.52) | GSK3BCHEK2MAPK1NTRK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |