Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | SPR | P35270 | 2/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | TKT | P29401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227369 | 0.84 | GSK3B (0.44) | GSK3BSIGMAR1CYP11B2TLR7PRMT5 | |
| SCHEMBL11231103 | 0.82 | MERTK (0.38) | SIGMAR1MERTKKDM1ASPR | |
| SCHEMBL11229121 | 0.80 | MEN1 (0.41) | SIGMAR1CYP11B2MERTKSPRMAPK1 | |
| SCHEMBL11245877 | 0.77 | GSK3B (0.45) | GSK3BTLR7SPRMAPK1 | |
| SCHEMBL11395666 | 0.75 | PRMT5 (0.41) | SIGMAR1CYP11B2KDM1APRMT5WDR77 | |
| SCHEMBL11244896 | 0.75 | GSK3B (0.49) | GSK3BSPRMAPK1 | |
| SCHEMBL11233480 | 0.75 | GSK3B (0.52) | GSK3BCYP11B2MAPK1CYP2A6 | |
| SCHEMBL11236115 | 0.74 | PIK3CB (0.46) | GSK3BCYP11B2TLR7SPRMAPK1 | |
| SCHEMBL11234436 | 0.73 | GSK3B (0.50) | GSK3BMAPK1 | |
| SCHEMBL11232434 | 0.72 | GSK3B (0.49) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| EP-0063754-A1 | Pyrazolopyridine derivatives, and preparation, useful as cardiotonics | STERLING DRUG INC. (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |