Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233480 | 0.80 | GSK3B (0.52) | GSK3BMKNK1MKNK2MAPK1 | |
| SCHEMBL11236115 | 0.79 | PIK3CB (0.46) | GSK3BSPRMAPK1KDR | |
| SCHEMBL11244896 | 0.78 | GSK3B (0.49) | GSK3BSPRMAPK1KDRMET | |
| SCHEMBL11127744 | 0.78 | SIGMAR1 (0.40) | SPRMKNK1MKNK2SIGMAR1METAP2 | |
| SCHEMBL11245877 | 0.77 | GSK3B (0.45) | GSK3BSPRMAPK1KDRFLT3 | |
| SCHEMBL11375927 | 0.76 | PRMT5 (0.45) | MKNK1MKNK2PRMT5WDR77METAP2 | |
| SCHEMBL11240784 | 0.71 | PDE3B (0.46) | MAPK1KDRFLT3 | |
| SCHEMBL11236404 | 0.70 | GSK3B (0.42) | GSK3BSPRMAPK1PRMT5WDR77 | |
| SCHEMBL11231193 | 0.69 | MAPK1 (0.39) | GSK3BMAPK1 | |
| SCHEMBL11229632 | 0.69 | GSK3B (0.52) | GSK3BMAPK1METAP2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361568-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1982-11-30 | — | — | US | disclosed |
| US-4264603-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |