Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237967 | 0.84 | POLB (0.39) | PDE7ARAB9AMAPTPDE4BPDE4D | |
| SCHEMBL11241318 | 0.82 | RAB9A (0.45) | PDE7ARAB9AMAPTPDE4BPDE4D | |
| SCHEMBL11235025 | 0.81 | RAB9A (0.40) | PDE7ARAB9AMAPTPDE4BPDE4D | |
| SCHEMBL11235418 | 0.78 | RAB9A (0.43) | PDE7ARAB9AMAPTPDE4BPDE4D | |
| SCHEMBL11246333 | 0.78 | PDE3B (0.45) | PDE7ARAB9AMAPTPDE4BPDE4D | |
| SCHEMBL11239183 | 0.78 | GCGR (0.36) | RAB9AMAPTNPC1 | |
| SCHEMBL11224797 | 0.76 | RAB9A (0.41) | PDE7ARAB9AMAPTPDE4BPDE4D | |
| SCHEMBL7278230 | 0.76 | PIK3R1 (0.36) | RAB9AMAPTNPC1 | |
| SCHEMBL11237097 | 0.75 | POLB (0.41) | PDE7ARAB9AMAPTPDE4BPDE4D | |
| SCHEMBL12354205 | 0.75 | CYP1A2 (0.42) | MAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |