Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11239183 | 0.84 | GCGR (0.36) | GCGRMAPK14MAPK10SMN1; SMN2GSK3B | |
| SCHEMBL7272675 | 0.79 | SQOR (0.40) | PIK3R1PIK3CASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7272903 | 0.79 | PDE3B (0.44) | PIK3R1PIK3CAGCGRMAPK14SMN1; SMN2 | |
| SCHEMBL11232696 | 0.78 | CYP2C19 (0.50) | PIK3CAGSK3BHTT | |
| SCHEMBL11155642 | 0.76 | CASP1 (0.51) | MAPTCCNCCDK8 | |
| SCHEMBL11233810 | 0.76 | PDE7A (0.43) | NPC1RAB9AMAPT | |
| SCHEMBL11241215 | 0.75 | KIF11 (0.37) | PIK3R1PIK3CAGCGRMAPK14SMN1; SMN2 | |
| SCHEMBL11172843 | 0.73 | RAB9A (0.37) | GCGRMAPK14MAPK10SMN1; SMN2GSK3B | |
| SCHEMBL11248447 | 0.72 | SMN1; SMN2 (0.40) | GCGRMAPK14SMN1; SMN2GSK3BHTT | |
| SCHEMBL11389347 | 0.71 | CASP1 (0.58) | GCGRMAPK14GSK3BMAPK1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4463008-A | 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0109027-A1 | Pyridine derivatives, process for their preparation and composition containing them | STERLING DRUG INC. (US) | 1984-05-23 | — | — | EP | disclosed |
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |