Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BCKDK | O14874 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240017 | 0.79 | KEAP1 (0.51) | KDM4EMAPTALDH1A1GAABCKDK | |
| SCHEMBL11253511 | 0.79 | KDM4E (0.42) | KDM4EMAPTGAABCKDKMCL1 | |
| Methane SCHEMBL11235653 | 0.78 | KEAP1 (0.50) | KDM4EMAPTALDH1A1GAABCKDK | |
| SCHEMBL11232073 | 0.78 | SIRT1 (0.44) | KDM4EMAPTALDH1A1BCKDKMCL1 | |
| SCHEMBL18903328 | 0.77 | GPR3 (0.50) | KDM4EMAPTALDH1A1ALOX5GAA | |
| Methane SCHEMBL11235493 | 0.77 | SIRT1 (0.43) | KDM4EMAPTALDH1A1BCKDKMCL1 | |
| SCHEMBL11250520 | 0.76 | CYP4F2 (0.47) | KDM4ESLC22A12ALOX15 | |
| SCHEMBL2308278 | 0.76 | KDM4E (0.41) | KDM4EMAPTALDH1A1ALOX5GAA | |
| SCHEMBL3258493 | 0.75 | KDM4E (0.61) | KDM4ECHRNA7MAPTALDH1A1GAA | |
| SCHEMBL24343656 | 0.75 | KDM4E (0.46) | KDM4EMAPTBCKDKMCL1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |