Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078693 | 0.88 | MKNK1 (0.56) | DHODHLMNAPDE3BPDE3APDE4A | |
| SCHEMBL7276070 | 0.85 | PDE3B (0.61) | KDM4EGAAHPGDHSD17B10DHODH | |
| SCHEMBL11234900 | 0.84 | PDE3B (0.61) | KDM4EGAAHPGDHSD17B10LMNA | |
| SCHEMBL11234641 | 0.83 | PDE3B (0.44) | KDM4EHPGDHSD17B10DHODHLMNA | |
| SCHEMBL11229029 | 0.83 | ALK (0.43) | KDM4EHPGDHSD17B10DHODHLMNA | |
| SCHEMBL11229059 | 0.82 | MKNK1 (0.43) | KDM4EHPGDHSD17B10LMNAPDE3B | |
| SCHEMBL11233117 | 0.80 | ALDH1A1 (0.47) | KDM4EGAAHPGDHSD17B10LMNA | |
| SCHEMBL11229727 | 0.80 | PDE3B (0.68) | KDM4EHPGDHSD17B10LMNAPDE3B | |
| SCHEMBL11238459 | 0.80 | ALK (0.48) | KDM4EHPGDHSD17B10LMNAPDE3B | |
| SCHEMBL2673559 | 0.79 | ALK (0.47) | KDM4EHPGDHSD17B10LMNAPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4312875-A | 5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof | STERLING DRUG INC. (US) | 1982-01-26 | — | — | US | disclosed |
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |
| US-4265895-A | 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-05-05 | — | — | US | disclosed |
| US-4264612-A | Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation and use as cardiotonics | STERLING DRUG INC. (US) | 1981-04-28 | — | — | US | disclosed |